Odile Harrison

About me
I studied Microbiology at the University College London and, after graduating in 1997, I undertook a research assistant position at Imperial College London which a year later turned into a PhD. The aim of my PhD was to study Neisseria meningitidis gene expression in vivo using a range of techniques including immunohistochemistry, confocal microscopy and in situ RT-PCR. I enjoyed my PhD immensely even though much of it was spent staring down a microscope and examining biopsies. Being half-French I was keen to work in France after my PhD, so I was very pleased to obtain a Marie Curie two year post-doctoral fellowship working within a pharmaceutical company in Lyon, France. There I started learning about iron acquisition in Neisseria and I also became aware of how to use bioinformatics tools for sequence analysis and how these can be used to study populations of bacteria.

This sparked my interest in population biology and sequence analysis and, after my post-doctoral position came to an end, I returned to the U.K and started working with Professor Martin Maiden in Oxford. There I have continued in my interest of iron acquisition systems in Neisseria and I have also diversified and studied other virulence determinants such as the capsule locus, all of this interspersed with a wedding and two children. Since October 2013, I have also started working on a Oxford Martin and Wellcome Trust funded project integrating genomic and immunological data with theoretical approaches to identify novel vaccine determinants targeting Neisseria gonorrhoeae and Chlamydia trachomatis.

I have also been interested in teaching and have recently become a fellow of the Higher Education Academy.

Research interests
Genomics, Population Biology, Infectious Diseases, Type IV secretion systems and encapsulated bacteria.

Contact
E-mail: odile.harrison@zoo.ox.ac.uk

Odile-web-small

Publications

Bennett JS, Watkins ER, Jolley KA, Harrison OB, Maiden MC. Identifying Neisseria species by use of the 50S ribosomal protein L6 (rplF) gene. J Clin Microbiol. 2014 May;52(5):1375-81. doi: 10.1128/JCM.03529-13. Epub 2014 Feb 12. PubMed PMID: 24523465; PubMed Central PMCID: PMC3993661.
Daugla DM, Gami JP, Gamougam K, Naibei N, Mbainadji L, Narbé M, Toralta J, Kodbesse B, Ngadoua C, Coldiron ME, Fermon F, Page AL, Djingarey MH, Hugonnet S,
Harrison OB, Rebbetts LS, Tekletsion Y, Watkins ER, Hill D, Caugant DA, Chandramohan D, Hassan-King M, Manigart O, Nascimento M, Woukeu A, Trotter C, Stuart JM, Maiden MC, Greenwood BM. Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study [corrected]. Lancet. 2014 Jan 4;383(9911):40-7. doi: 10.1016/S0140-6736(13)61612-8. Epub 2013 Sep 12. Erratum in: Lancet. 2014 Jan 4;383(9911):30. PubMed PMID: 24035220; PubMed Central PMCID: PMC3898950.
Harrison OB, Bennett JS, Derrick JP, Maiden MC, Bayliss CD. Distribution and diversity of the haemoglobin-haptoglobin iron-acquisition systems in pathogenic and non-pathogenic Neisseria. Microbiology. 2013 Sep;159(Pt 9):1920-30. doi: 10.1099/mic.0.068874-0. Epub 2013 Jun 27. PubMed PMID: 23813677; PubMed Central PMCID: PMC3783016.
Harrison OB, Claus H, Jiang Y, Bennett JS, Bratcher HB, Jolley KA, Corton C, Care R, Poolman JT, Zollinger WD, Frasch CE, Stephens DS, Feavers I, Frosch M, Parkhill J, Vogel U, Quail MA, Bentley SD, Maiden MC. Description and nomenclature of Neisseria meningitidis capsule locus. Emerg Infect Dis. 2013 Apr;19(4):566-73. doi: 10.3201/eid1904.111799. PubMed PMID: 23628376; PubMed Central PMCID: PMC3647402.
Jolley KA, Hill DM, Bratcher HB, Harrison OB, Feavers IM, Parkhill J, Maiden MC. Resolution of a meningococcal disease outbreak from whole-genome sequence data with rapid Web-based analysis methods. J Clin Microbiol. 2012 Sep;50(9):3046-53. doi: 10.1128/JCM.01312-12. Epub 2012 Jul 11. PubMed PMID: 22785191; PubMed Central PMCID: PMC3421817.
Jolley KA, Bliss CM, Bennett JS, Bratcher HB, Brehony C, Colles FM, Wimalarathna H, Harrison OB, Sheppard SK, Cody AJ, Maiden MC. Ribosomal multilocus sequence typing: universal characterization of bacteria from domain to strain. Microbiology. 2012 Apr;158(Pt 4):1005-15. doi: 10.1099/mic.0.055459-0. Epub 2012 Jan 27. PubMed PMID: 22282518; PubMed Central PMCID: PMC3492749.
Harrison OB, Brueggemann AB, Caugant DA, van der Ende A, Frosch M, Gray S, Heuberger S, Krizova P, Olcen P, Slack M, Taha MK, Maiden MC. Molecular typing methods for outbreak detection and surveillance of invasive disease caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, a review. Microbiology. 2011 Aug;157(Pt 8):2181-95. doi: 10.1099/mic.0.050518-0. Epub 2011 May 26. Review. PubMed PMID: 21622526; PubMed Central PMCID: PMC3980633.
Tauseef I, Harrison OB, Wooldridge KG, Feavers IM, Neal KR, Gray SJ, Kriz P, Turner DP, Ala’Aldeen DA, Maiden MC, Bayliss CD. Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence. Microbiology. 2011 May;157(Pt 5):1446-56. doi: 10.1099/mic.0.046946-0. Epub 2011 Feb 10. PubMed PMID: 21310784; PubMed Central PMCID: PMC3352162.
Aspholm M, Aas FE, Harrison OB, Quinn D, Vik A, Viburiene R, Tønjum T, Moir J, Maiden MC, Koomey M. Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans. PLoS Pathog. 2010 Aug 19;6(8):e1001055. doi: 10.1371/journal.ppat.1001055. PubMed PMID: 20808844; PubMed Central PMCID: PMC2924362.
Evans NJ, Harrison OB, Clow K, Derrick JP, Feavers IM, Maiden MC. Variation and molecular evolution of HmbR, the Neisseria meningitidis haemoglobin receptor. Microbiology. 2010 May;156(Pt 5):1384-93. doi: 10.1099/mic.0.036475-0. Epub 2010  Feb 11. PubMed PMID: 20150237; PubMed Central PMCID: PMC3068627.
Harrison OB, Evans NJ, Blair JM, Grimes HS, Tinsley CR, Nassif X, Kriz P, Ure R, Gray SJ, Derrick JP, Maiden MC, Feavers IM. Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence. J Infect Dis. 2009 Jul 1;200(1):94-8. doi: 10.1086/599377. PubMed PMID: 19476432; PubMed Central PMCID: PMC2731217.
Srikhanta YN, Dowideit SJ, Edwards JL, Falsetta ML, Wu HJ, Harrison OB, Fox KL, Seib KL, Maguire TL, Wang AH, Maiden MC, Grimmond SM, Apicella MA, Jennings MP. Phasevarions mediate random switching of gene expression in pathogenic Neisseria. PLoS Pathog. 2009 Apr;5(4):e1000400. doi: 10.1371/journal.ppat.1000400. Epub 2009 Apr 24. PubMed PMID: 19390608; PubMed Central PMCID: PMC2667262.
Harrison OB, Maiden MC, Rokbi B. Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species. BMC Microbiol. 2008 Apr 22;8:66.  doi: 10.1186/1471-2180-8-66. PubMed PMID: 18430216; PubMed Central PMCID: PMC2386816.
Harrison OB, Robertson BD, Faust SN, Jepson MA, Goldin RD, Levin M, Heyderman RS. Analysis of pathogen-host cell interactions in purpura fulminans: expression of capsule, type IV pili, and PorA by Neisseria meningitidis in vivo. Infect Immun. 2002 Sep;70(9):5193-201. PubMed PMID: 12183570; PubMed Central PMCID: PMC128269.
Faust SN, Levin M, Harrison OB, Goldin RD, Lockhart MS, Kondaveeti S, Laszik Z, Esmon CT, Heyderman RS. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med. 2001 Aug 9;345(6):408-16. PubMed PMID: 11496851.