Dorothea Hill

About me
I am in the third year of my D.Phil., which focuses on establishing the MRF Meningococcus Genome Library and the first epidemiological and population analyses of the data. I joined Martin Maiden’s group in 2010 after graduating from the University of Oxford where I read Biological Sciences. At this time I was working for the MenAfriCar consortium, diagnosing the serogroups of meningococcal isolates from the African meningitis belt prior to the introduction of the MenAfriVac vaccine. I started my D.Phil. in 2011. In collaboration with Public Health England and the Sanger Institute, I have been carrying out bioinformatic analysis of around 1500 whole-genome sequences from all meningococcal disease isolates collected in England, Wales, and Northern Ireland from 2010-2013. I am particularly interested in bacterial population diversity and the ecological structuring of pathogen transmission. I am a member of the Meningitis Research Foundation, and, in addition to our academic work (http://www.meningitis.org/current-projects/genome), I have enjoyed taking part in fundraising activities such as the MRF 25th Anniversary Walk.

Research interests
I am interested in: using next-generation sequencing methods to study the population genetics of pathogenic bacteria; the genomic diversity of meningococcal populations and lineages; spatial and temporal transmission patterns in hyperinvasive meningococcal lineages.

Contact
E-mail: dorothea.hill@zoo.ox.ac.uk


DSC03053-1

Publications

Jolley KA, Hill DM, Bratcher HB, Harrison OB, Feavers IM, et al. (2012) Resolution of a meningococcal disease outbreak from whole genome sequence data with rapid web-based analysis methods. Journal of Clinical Microbiology.

Daugla DM, Gami JP, Gamougam K, Naibei N, Mbainadji L, et al. (2014) Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study [corrected]. Lancet 383: 40-47.